Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway
نویسندگان
چکیده
منابع مشابه
Myeloma cells inhibit osteogenic differentiation of mesenchymal stem cells and kill osteoblasts via TRAIL-induced apoptosis
INTRODUCTION Myeloma bone disease (MBD) is the result of the increased activity of osteoclasts (OCs), which is not accompanied by a comparable increase of osteoblast (OB) function, thus leading to enhanced bone resorption. Osteoblasts can also regulate osteoclast activity through expression of cytokines, such as receptor activator of nuclear factor-κB ligand (RANKL), which activates osteoclast ...
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Multiple myeloma (MM) always presents osteolytic bone lesions, resulting from the abnormal osteoblastic and osteoclastic function in patients. MM patients exhibit the impairment of osteogenic differentiation of BMMSCs (bone marrow mesenchymal stem cells) and osteoblast deficiency. Effects of the drug, lenalidomide on the osteoblastic functions and the involved mechanisms remain unexplored. In t...
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In recent years, mesenchymal stem cells (MSCs), which possess the ability to specifically home to tumor sites, with the potential of multi-directional differentiation and low immunogenicity, have been reported to inhibit the growth of various types of tumors. In the present study, we isolated MSCs from the rib perichondrium (PMSCs). By comparing PMSCs with bone marrow‑derived mesenchymal stem c...
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Multiple myeloma (MM) remains incurable despite much progress that has been made in the treatment of the disease. MM cancer stem cell (MMSC), a rare subpopulation of MM cells with the capacity for self-renewal and drug resistance, is considered to lead to disease relapse. Several markers such as side population (SP) and ALDH1+ have been used to identify MMSCs. However, ideally and more precisel...
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Mesenchymal stem cells (MSCs) as a kind of adult stem cells possess two properties of long term selfrenewal ability and multilineage differentiation potential into skeletal cell lineages. MSCs were first isolated and described from bone marrow samples. Further investigations have identified several other tissues as alternative sources for these cells. In spite of the clinical importance of MSCs...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2013
ISSN: 1757-6512
DOI: 10.1186/scrt322